An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Title:An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH

Volume: 9 Issue: 9

Author(s): Ling-ling Zhao, Yu Wan, Hai-ying Wang, Chao Wang, Xiao-xiao Zhang, Shu-ying Huang, Gui-xiang Liu, Liang-feng Chen and Hui Wu

Affiliation:

Keywords: Basic ionic liquid, pyrazolo[3, 4-b]pyridines, infertility, addiction, symptoms, inhibitors, three-component reaction, pKa, steric hindrance, recrystallized

Abstract: Chain 1,3-dicarbonyl compounds were firstly used as starting material to react with 5-amino-3-methyl-1- phenylpyrazol and aromatic aldehydes to prepare 1H-pyrazolo[3,4-b]pyridines in basic ionic liquid [bmim]OH. The onestep three-component reaction is simple and efficient. Additionally, water was the only one by-product during the whole process.

Cite this article as:

Zhao Ling-ling, Wan Yu, Wang Hai-ying, Wang Chao, Zhang Xiao-xiao, Huang Shu-ying, Liu Gui-xiang, Chen Liang-feng and Wu Hui, An Efficient One-Step Synthesis of 1H-pyrazolo[3,4-b]pyridines in Basic Ionic Liquid [bmim]OH, Letters in Organic Chemistry 2012; 9 (9) . https://dx.doi.org/10.2174/157017812803521144