Title:Enantioselective Addition of Diethylzinc to Aldehydes by Chiral Oxazolidine–Titanium Complex
VOLUME: 9 ISSUE: 9
Author(s):Nan Wu, Rongcheng Bo, Rongli Zhang, Xi Jiang, Yu Wan, Zhou Xu and Hui Wu
Affiliation:College of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou 221116, P. R. China.
Keywords:Asymmetric alkynylation, enantioselectivity oxazolidine, secondary alcohol, Chiral, dialkylzinc reagents, schlenk tube, organic layer, UV detection, Aldrich, chelating group
Abstract:A series of chiral oxazolidines derived from (1R, 2S)-cis-1-amino-2-indanol was found to be effective in
promoting the asymmetric addition of diethylzinc to aldehydes. Among the ligands developed, it was found that ligand 1b
in the presence of Ti(OiPr)4 yielded the highest enantioselectivities when it was applied in the catalytic asymmetric addition
of diethylzinc to aldehydes (up to 91% ee).
