Title:Dendrimers As Vectors for Genetic Material Delivery to the Nervous System
VOLUME: 19 ISSUE: 29
Author(s):F.C. Perez-Martinez, A.V. Ocana, M.D. Perez-Carrion and V. Cena
Affiliation:Unidad Asociada Neurodeath, Facultad de Medicina, Avda. Almansa, 14, 02006 Albacete, Spain.
Keywords:Blood-brain barrier, dendrimers, DNA, glioblastoma, neurons, siRNA, transfection
Abstract:Transfection of genetic material into primary neuronal cultures remains a challenge because of the intrinsic difficulty in transfecting
this type of cell. This review covers the recent developments in the use of dendrimers for siRNA and DNA transfection in both
neuronal and glial cells. Crossing the blood brain barrier crossing represents a challenge for the effective use of dendrimer-mediated delivery
of therapeutic agents to the central nervous system. We will discuss the effectiveness, both in vitro and in vivo, of various dendrimers
in delivering genetic material to neural tissue and its ability to cross the blood-brain barrier. In addition, the use of dendrimers as
a potential new therapy in the treatment of glioblastoma will be presented.
