Title:The Seemingly Trivial Yet Challenging Synthesis of Poly(aminoester) Dendrimers
VOLUME: 19 ISSUE: 29
Author(s):Y. Wang, G. Quelever and L. Peng
Affiliation:Centre Interdisciplinaire de Nanoscience de Marseille, CNRS UMR 7325, Departement de Chimie, 163, avenue de Luminy, 13288 Marseille cedex 09, France.
Keywords:Biodegradable dendrimer, click chemistry, dendrimer, drug delivery, nanocarriers, poly(aminoester)
Abstract:Poly(aminoester) dendrimers are expected to hold great promise as biodegradable nanocarriers for drug delivery due to their
advantageous properties allowing their biodegradability, potentially lower toxicity and possibility of diverse chemical conjugations. The
synthetic strategies for constructing such dendrimers include the amine branching method, the ester formation method, the combination
of both methods as well as the recently emerging click chemistry based synthesis. We present here an overview on the current state of
synthesizing poly(aminoester) dendrimers and discuss the benefits and limitations of each strategy with a view to stimulating a fueled interest
in the development of efficient and reliable methodologies to synthesize such dendrimers.
