Celiac disease is a multi-systemic autoimmune disease of the small bowel induced by gluten in genetically predisposed subjects.
Highly specific and gluten-dependent production of auto-antibodies targeting self-proteins of the transglutaminase family occurs in
the intestinal mucosa. These anti-transglutaminase antibodies are found deposited in intestinal and extra-intestinal tissue where they
might exert biological effects, together with the intestinal mucosal gliadin-specific T lymphocytes. We conducted a brief review on antitransglutaminase
antibodies effects, discussing their roles in the pathogenesis of several clinical manifestations of celiac disease.