Title:Review of Evidence that Epidemics of Type 1 Diabetes and Type 2 Diabetes/ Metabolic Syndrome are Polar Opposite Responses to Iatrogenic Inflammation
VOLUME: 8 ISSUE: 6
Author(s):John B. Classen
Affiliation:Classen Immunotherapies, Inc. 3637 Rockdale Road, Manchester, MD 21102, USA.
Keywords:Diabetes, vaccine, immunization, inflammation, metabolic syndrome, obesity, type 1 diabetes, cortisol, Cushingoid state, microalbuminuria, hypertension, adolescents, hyperlipidemia, 11-beta hydroxysteroid dehydrogenase.
Abstract:There is an epidemic in children of metabolic syndrome, obesity, type 2 diabetes and other individual diseases
that form the components of metabolic syndrome. Poor diet and low exercise can not explain many facets of the epidemic
including the onset in children 6 month of age, the protective effect of obesity on the incidence of type 1 diabetes and the
epidemic of type 2 diabetes/metabolic syndrome in grass fed horses. Poor diet and exercise also do not explain the epidemic
of type 1 diabetes in children that resembles the epidemic of type 2 diabetes/metabolic syndrome. Several papers
have been published to indicate that the epidemics of type 1 and type 2 diabetes/metabolic syndrome in children are linked
and are polar opposite responses to iatrogenic inflammation. Several lines of research support this. Data from different
races indicates that there is an inverse relationship between developing type 1 diabetes and type 2 diabetes. Races with
high risk of developing type 2 diabetes have a decreased risk of developing type 1 diabetes. Data from Italy confirmed an
inverse association between obesity and type 1 diabetes. Further studies indicate the inverse relationship between type 1
diabetes and type 2 diabetes/obesity is due to cortisol production. Data indicates those with low cortisol responses have a
predilection for type 1 diabetes and other autoimmune disorders following inflammation, while those with high cortisol/
immune suppressive responses develop type 2 diabetes/metabolic syndrome/obesity which resembles a Cushingoid
state but are spared in the autoimmune disorders. Japanese children produce much more cortisol following immunization
than Caucasian children. The later explains why discontinuation of BCG vaccination was associated with a decrease in
type 1 diabetes in European children and a decrease in type 2 diabetes in Japanese children. Both the epidemics of type 1
diabetes and metabolic syndrome correlate with an increase in immunization. Finally, there is a strong mechanism data
that macrophage produced interleukin 1, tumor necrosis factor and interleukin 6, which are released following inflammation,
causing destruction of insulin secreting islet cells and increase cortisol release, and thus have the ability to cause both
type 1 and type 2 diabetes/metabolic syndrome (which resembles a Cushingoid state). The propensity to develop type 1
diabetes or type 2 diabetes/metabolic syndrome depends on the propensity to release of cortisol which correlates with
race.
