Neurodegenerative disorders (NDs) are rapidly increasing as population ages. However, successful treatments
for NDs have so far been limited and drug delivery to the brain remains one of the major challenges to overcome. There
has recently been growing interest in the development of drug delivery systems (DDS) for local or systemic brain administration.
DDS are able to improve the pharmacological and therapeutic properties of conventional drugs and reduce their
side effects. The present review provides a concise overview of the recent advances made in the field of brain drug
delivery for treating neurodegenerative disorders. Examples include polymeric micro and nanoparticles, lipidic
nanoparticles, pegylated liposomes, microemulsions and nanogels that have been tested in experimental models of
Parkinson’s, Alzheimer’s and Hungtinton’s disease. Overall, the results reviewed here show that DDS have great potential
for NDs treatment.
Keywords: Drug delivery systems, neurodegenerative disorders, stereotactic surgery, blood brain barrier, Alzheimer’s disease (AD), pharmacological and therapeutic properties, conventional drugs, neurodegenerative disorders, polymeric micro, lipidic nanoparticles, pegylated liposomes, Parkinson’s disease (PD), microemulsion, drug delivery
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