Utility of Assessing Thiopurine S-methyltransferase Polymorphisms Before Azathioprine Therapy

Author(s): Teresa Cabaleiro, Manuel Roman, Javier P. Gisbert, Francisco Abad-Santos

Journal Name: Current Drug Metabolism

Volume 13 , Issue 9 , 2012


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Abstract:

Thiopurine S-methyltransferase (TPMT) catalyzes the methylation of thiopurine drugs, such as azathioprine and mercaptopurine, which are used in a variety of diseases. Several mutations in the TPMT gene correlate with low enzyme activity and subsequent adverse effects, mainly myelotoxicity. Hence, genotyping TPMT makes it possible to identify patients at high risk of drug toxicity and adjust dosage accordingly. However, further research about the availability of a reliable and universal screening method and more costeffectiveness studies are necessary.

Keywords: Thiopurine S-methyltransferase, azathioprine, polymorphism, genotyping

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Article Details

VOLUME: 13
ISSUE: 9
Year: 2012
Published on: 03 October, 2012
Page: [1277 - 1293]
Pages: 17
DOI: 10.2174/138920012803341311
Price: $65

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