Abstract
Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elicit cytotoxic effector functions against circulating tumor cells and distant metastases. Heat shock proteins (HSPs, also termed stress proteins) are involved in antigen processing and presentation and can act as “danger signals” for the adaptive and innate immune systems. This article reviews current knowledge relating to the induction and manifestation of stress protein-related immunological responses that are pertinent to the development and maintenance of protective anti-tumor immunity.
Keywords: Adaptive immunity, antigen presentation, dendritic cells, immunogenic cell death, innate immunity, macrophages, NK cells, T cells, cytokines, stress proteins, chemotherapy, lymph nodes, tumors, metastases, phenotype
Current Molecular Medicine
Title:Dual Role of Heat Shock Proteins (HSPs) in Anti-Tumor Immunity
Volume: 12 Issue: 9
Author(s): G. Multhoff, A.G. Pockley, C. Streffer and U.S. Gaipl
Affiliation:
Keywords: Adaptive immunity, antigen presentation, dendritic cells, immunogenic cell death, innate immunity, macrophages, NK cells, T cells, cytokines, stress proteins, chemotherapy, lymph nodes, tumors, metastases, phenotype
Abstract: Although surgery and radiotherapy are highly efficient in local tumor control, distal metastases and tumor recurrence often limit therapeutic outcome. It is becoming progressively more evident that curative tumor therapy depends on the presence and maintenance of an intact immune system which has the capacity to elicit cytotoxic effector functions against circulating tumor cells and distant metastases. Heat shock proteins (HSPs, also termed stress proteins) are involved in antigen processing and presentation and can act as “danger signals” for the adaptive and innate immune systems. This article reviews current knowledge relating to the induction and manifestation of stress protein-related immunological responses that are pertinent to the development and maintenance of protective anti-tumor immunity.
Export Options
About this article
Cite this article as:
Multhoff G., Pockley A.G., Streffer C. and Gaipl U.S., Dual Role of Heat Shock Proteins (HSPs) in Anti-Tumor Immunity, Current Molecular Medicine 2012; 12 (9) . https://dx.doi.org/10.2174/156652412803306666
DOI https://dx.doi.org/10.2174/156652412803306666 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Liver and Pancreatic Disease in Cystic Fibrosis: Clinics and Drug Therapy
Clinical Immunology, Endocrine & Metabolic Drugs (Discontinued) HIV-1 Infection in Subjects Older than 70: A Multicenter Cross-Sectional Assessment in Catalonia, Spain
Current HIV Research Insulin and the Brain
Current Diabetes Reviews All for Statins and Statins for All; An Update
Current Pharmaceutical Design Drugs for the Treatment of Hypercholesterolemia and their Benefits Beyond Cholesterol Lowering to Prevent Vascular Disease
Vascular Disease Prevention (Discontinued) G Protein β γ Subunits as Targets for Small Molecule Therapeutic Development
Combinatorial Chemistry & High Throughput Screening Prevention of Renal Complications Induced by Non- Steroidal Anti-Inflammatory Drugs
Current Medicinal Chemistry Bosentan in Pediatric Patients with Pulmonary Arterial Hypertension
Current Vascular Pharmacology Relaxin, Insulin and Diabetes: An Intriguing Connection
Current Diabetes Reviews Development of Nitrendipine Nanoliposome for Transdermal Drug Delivery: Preparation, Characterization and Permeation Studies
Drug Delivery Letters SLS-catalyzed Multi-component One-pot Reactions for the Convenient Synthesis of Spiro[indoline-3,4’-pyrano [2,3-c]pyrazole] Derivatives
Current Organocatalysis Sympathetic Mechanisms of Hypoglycemic Counterregulation
Current Diabetes Reviews Design, Optimization, Preparation and Evaluation of Dispersion Granules of Valsartan and Formulation into Tablets
Current Drug Delivery Optimizing Target Selection and Development Strategy in Cancer Treatment; The Next Wave
Current Medicinal Chemistry - Anti-Cancer Agents Medical Systemic Therapies for Hepatocellular Carcinoma: Clinical Perspectives and Safety Profile
Current Drug Safety Update on the Protective Renal Effects of Metformin in Diabetic Nephropathy
Current Medicinal Chemistry Non-transfusion Dependent Thalassemias: A Developing Country Perspective
Current Pediatric Reviews Diabetic Nephropathy: Causes and Managements
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery Glucocorticoids and Vascular Reactivity
Current Vascular Pharmacology Obesity: Current Treatment and Future Horizons
Mini-Reviews in Medicinal Chemistry