Convection Enhanced Delivery of Macromolecules for Brain Tumors

Author(s): Ankit I. Mehta, Bryan D. Choi, Divya Ajay, Raghu Raghavan, Martin Brady, Allan H. Friedman, Ira Pastan, Darell D. Bigner, John H. Sampson

Journal Name: Current Drug Discovery Technologies

Volume 9 , Issue 4 , 2012

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Abstract:

The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.

Keywords: Convection enhanced delivery, drug delivery system, glioblastoma, surrogate markers, tracers, blood brain barrier (BBB), Brain Tumors, macromolecules, surgical resection, radiation therapy

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2012
Page: [305 - 310]
Pages: 6
DOI: 10.2174/157016312803305951
Price: $65

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