Translational Animal Models in Drug Discovery and Development

Editor(s): Xinkang Wang

Indexed in: Scopus, EBSCO.

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Animal models of diseases play a pivotal role in drug discovery and development, not only for proof of the concept studies of efficacy, PK/PD relationship but also for drug safety assessment. Since ...
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Foreword  promotion: free to download

Pp. i-iii (3)

Giora Feuerstein

Preface  promotion: free to download

Pp. iv-vii (4)

Xinkang Wang

List of Contributors  promotion: free to download

Pp. viii-ix (2)

Xinkang Wang

Animal Models of Atherosclerosis and Spontaneous Plaque Rupture

Pp. 3-23 (21)

Andrew R. Bond and Christopher L. Jackson

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Animal Models of Ischemic Stroke: Issues in Translational Congruency

Pp. 42-66 (25)

Frank C. Barone, Daniel M. Rosenbaum, Jie Li, Jin Zhou and Xinkang Wang

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Mouse Models of Coagulation Factor Deficiencies for Translational Research

Pp. 67-121 (55)

Meghann P. McManus and David Gailani

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Xenograft Models of the Normal and Malignant Human Breast  Open Access Plus

Pp. 122-138 (17)

Michael T. Lewis

BALB-neuT Female Mice as a Dynamic Model of Mammary Cancer

Pp. 139-166 (28)

Manuela Iezzi, Raffaele A. Calogero, Michela Spadaro, Piero Musiani, Guido Forni and Federica Cavallo

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Modeling Human Asthma in Animals

Pp. 167-195 (29)

Jason H.T. Bates, Mercedes Rincon and Charles G. Irvin

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In Vivo Veritas: Preclinical Models of Human Arthritic Disease in Non-Human Primates

Pp. 247-273 (27)

Michel Vierboom and Elia Breedveld

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Pp. 274-275 (2)

Xinkang Wang