In an attempt to find a new class of antimicrobial agents, a series of novel pyrazol-1-yl-4-substitutedthiazole 4
(a-j) were synthesized. The 1,3-diphenylprop-2-en-1-one (1) was treated with thiosemicarbazide to obtain 3,5-diphenyl-
4,5-dihydro-1H-pyrazole-1-carbothioamide (2), which was then reacted with substituted phenacyl bromides in ethanol to
obtain final compound 2-(3,5-diphenyl-4,5-dihydro-1H-pyrazol-1-yl)-4-substitutedthiazoles 4 (a-j). The synthesized
compounds were confirmed by melting point, IR, 1H-NMR, 13C NMR and Mass spectroscopy. All the synthesized
compounds were screened for antimicrobial activity among the tested series, 4c exhibited significant antibacterial activity
against gram positive bacteria (Staphylococcus aureus and Bacillus subtilis) and 4d against gram negative E.coli.
Similarly 4c and 4d showed significant antifungal activity (31.25 μg/mL) when compared to fluconazole against C.