Title:Chromatin Remodeling, DNA Damage Repair and Aging
VOLUME: 13 ISSUE: 7
Author(s):Baohua Liu, Raymond K.H Yip and Zhongjun Zhou
Affiliation:Department of Biochemistry, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 21 Sassoon Road, Pok Fu Lam, Hong Kong.
Keywords:Aging, Longevity, Epigenetics, Sirtuins, Histone modifications, DNA double strand break repair
Abstract:Cells are constantly exposed to a variety of environmental and endogenous conditions causing DNA damage,
which is detected and repaired by conserved DNA repair pathways to maintain genomic integrity. Chromatin remodeling
is critical in this process, as the organization of eukaryotic DNA into compact chromatin presents a natural barrier to all
DNA-related events. Studies on human premature aging syndromes together with normal aging have suggested that accumulated
damages might lead to exhaustion of resources that are required for physiological functions and thus accelerate
aging. In this manuscript, combining the present understandings and latest findings, we focus mainly on discussing the
role of chromatin remodeling in the repair of DNA double-strand breaks (DSBs) and regulation of aging.
