Title:Changes of Gene Expression in the Developing Brain by Acute Ethanol Exposure
VOLUME: 1 ISSUE: 4
Author(s):Nayoung Kim, Sang Soo Kang and Wan Sung Choi
Affiliation:Department of Anatomy and Neurobiology, Medical Research Center for Neural Dysfunction, and Institute of Health Science, School of Medicine, Gyeongsang National University, 92 Chilam-dong, Jinju, Gyeongnam 660-751, South Korea.
Keywords:Transcriptome analysis, fetal alcohol spectrum disorder, fetal alcohol syndrome, Acute Ethanol Exposure, cDNA microarray, FASD, synaptogenesis, TNFRSF1A, PI3K signaling pathways, glycolysis , neurodegeneration, neuroinflammation, brain damage, dysmorphism, glandular tissues
Abstract:Ethanol is one of the most common teratogens, causing a broad range of physiological, neuronal and behavioral
problems, named as fetal alcohol spectrum disorder (FASD). Expression of various molecules involved in apoptosis,
signaling pathways, and innate immune system, has been shown to change upon acute ethanol exposure. Gene expression
profiling has been attempted by several groups, but comprehensive understanding is required, considering different
experimental protocols used by each group. In this review, we summarize previously published reports of transcriptome
analyses and our own previously unpublished results of cDNA microarray, according to developmental stages of brain and
discuss about what we have learned from the results.
