Abstract
C5-position in pyrimidine nucleosides and nucleotides is an invaluable anchor point for tagging diverse kind of labels like haptens, dyes and signaling molecules. Oligonucleotides with such C5-modified pyrimidine nucleosides and nucleotides are being used in molecular genetics and next generation nucleic acid sequencing as indispensable diagnostic tools. In view of their requirement in a wide range of primers and probes, chemistry synthesis and manufacture of C5-modified substituted pyrimidines had elicited continued interest over the last several decades. These diverse classes of molecules also have pharmaceuticals significance. The objective of this review is to capture the recent strategies available to synthesize C5-modified pyrimidine nucleosides and nucleotides that include organometallic, “Click” and photochemistry.
Keywords: Click chemistry, Organometallic coupling, C5-halopyrimidines, C5-substituted pyrimidine nucleosides, nucleotides, organometallic, photochemistry, Oligonucleotides, nucleotides and organometallic
Current Organic Chemistry
Title:Recent Developments in the Synthesis and Applications of C5-Substituted Pyrimidine Nucleosides and Nucleotides
Volume: 16 Issue: 17
Author(s): Anilkumar R. Kore and Irudaya Charles
Affiliation:
Keywords: Click chemistry, Organometallic coupling, C5-halopyrimidines, C5-substituted pyrimidine nucleosides, nucleotides, organometallic, photochemistry, Oligonucleotides, nucleotides and organometallic
Abstract: C5-position in pyrimidine nucleosides and nucleotides is an invaluable anchor point for tagging diverse kind of labels like haptens, dyes and signaling molecules. Oligonucleotides with such C5-modified pyrimidine nucleosides and nucleotides are being used in molecular genetics and next generation nucleic acid sequencing as indispensable diagnostic tools. In view of their requirement in a wide range of primers and probes, chemistry synthesis and manufacture of C5-modified substituted pyrimidines had elicited continued interest over the last several decades. These diverse classes of molecules also have pharmaceuticals significance. The objective of this review is to capture the recent strategies available to synthesize C5-modified pyrimidine nucleosides and nucleotides that include organometallic, “Click” and photochemistry.
Export Options
About this article
Cite this article as:
R. Kore Anilkumar and Charles Irudaya, Recent Developments in the Synthesis and Applications of C5-Substituted Pyrimidine Nucleosides and Nucleotides, Current Organic Chemistry 2012; 16 (17) . https://dx.doi.org/10.2174/138527212803251622
DOI https://dx.doi.org/10.2174/138527212803251622 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Advances of Heterocyclic Chemistry with Pesticide Activity
Global food safety and security will continue to be a global concern for the next 50 years and beyond. Plant diseases have had a significant impact on food safety and security throughout the entire food chain, from primary production to consumption. While conventional chemical pesticides have been traditionally used for ...read more
Calculation design of covalent/metal organic framework based catalysts
This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Synergism of Temozolomide, Metformin, and Epigallocatechin Gallate Promotes Oxidative Stress-Induced Apoptosis in Glioma Cells
Current Drug Therapy Strategies for Development of Antimalarials Based on Encapsulated Porphyrin Derivatives
Mini-Reviews in Medicinal Chemistry Recent Insights into COVID-19 in Children and Clinical Recommendations
Current Pediatric Reviews Sialic Acid and the Central Nervous System: Perspectives on Biological Functions, Detection, Imaging Methods and Manipulation
CNS & Neurological Disorders - Drug Targets Evaluation of the Effects of 1,25 Vitamin D3 on Regulatory T Cells and T Helper 17 Cells in Vitamin D-deficient Women with Unexplained Recurrent Pregnancy Loss
Current Molecular Pharmacology Identification and Characterization of a Chemical Compound that Inhibits Methionyl-tRNA Synthetase from <i>Pseudomonas aeruginosa</i>
Current Drug Discovery Technologies Quantization of Angiogenesis and Image Analysis
Current Angiogenesis (Discontinued) G-Quadruplex Based Probes for Visual Detection and Sensing
Current Pharmaceutical Design Modulation of pRb/E2F Functions in the Regulation of Cell Cycle and in Cancer
Current Cancer Drug Targets Stimuli-induced Pulsatile or Triggered Release Delivery Systems for Bioactive Compounds
Recent Patents on Endocrine, Metabolic & Immune Drug Discovery An Updated Review on <i>Betacoronavirus</i> Viral Entry Inhibitors: Learning from Past Discoveries to Advance COVID-19 Drug Discovery
Current Topics in Medicinal Chemistry Review of Progress in Predicting Protein Methylation Sites
Current Organic Chemistry An Apple Plus a Brazil Nut a Day Keeps the Doctors Away: Antioxidant Capacity of Foods and their Health Benefits
Current Pharmaceutical Design Electrochemical Biosensors as a Screening Tool of In Vitro DNA-Drug Interaction
Current Pharmaceutical Analysis Tumor Physiology and Charge Dynamics of Anticancer Drugs: Implications for Camptothecin-based Drug Development
Current Medicinal Chemistry Ion Channel Screening Technology
CNS & Neurological Disorders - Drug Targets Allosteric Modulation of Nicotinic Acetylcholine Receptors: The Concept and Therapeutic Trends
Current Pharmaceutical Design Synthesis, in Vitro and in Vivo Anticancer Activity of Hybrids of 3- Hydroxy-indolin-2-one and 2,3-Dihydroquinolin-4(1H)-one
Letters in Drug Design & Discovery Metallodendrimers and Dendrimer Nanocomposites
Current Pharmaceutical Design Irreversible Inhibition of Serine Proteases – Design and In Vivo Activity of Diaryl α-Aminophosphonate Derivatives
Current Medicinal Chemistry