Pathophysiology of Coronary Thrombus Formation and Adverse Consequences of Thrombus During PCI

Author(s): Sundararajan Srikanth, John A. Ambrose

Journal Name: Current Cardiology Reviews

Volume 8 , Issue 3 , 2012

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Abstract:

Atherosclerosis is a systemic vascular pathology that is preceded by endothelial dysfunction. Vascular inflammation "fuels" atherosclerosis and creates the milieu for episodes of intravascular thromboses. Thrombotic events in the coronary vasculature may lead to asymptomatic progression of atherosclerosis or could manifest as acute coronary syndromes or even sudden cardiac death. Thrombus encountered in the setting of acute coronary syndromes has been correlated with acute complications during percutaneous coronary interventions such as no-reflow, acute coronary occlusion and long term complications such as stent thrombus. This article reviews the pathophysiology of coronary thrombogenesis and explores the complications associated with thrombus during coronary interventions.

Keywords: Coronary thrombus, percutaneous intervention, endothelial dysfunction, atherosclerosis

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Article Details

VOLUME: 8
ISSUE: 3
Year: 2012
Page: [168 - 176]
Pages: 9
DOI: 10.2174/157340312803217247
Price: $65

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