Title:Technological Barriers in the Use of Electrochemical Microsensors and Microbiosensors for in vivo Analysis of Neurological Relevant Substances
VOLUME: 10 ISSUE: 3
Author(s):Bogdan Bucur
Affiliation:National Institute of Research and Development for Biological Sciences, Bioanalysis Center, 296 Splaiul Independentei, 060031, Bucharest, Romania.
Keywords:Brain in vivo analysis, microelectrodes, microbiosensors, neurotransmitters, neuromodulators
Abstract:In this paper is presented an overview of the technological barriers faced by the in vivo brain analysis with
microelectrodes. Numerous microsensors and enzymatic microbiosensors have been developed for the real time
monitoring of neurotransmitters, neuromodulators, drugs and diverse other biological relevant substances. A clear
understanding of the working principle, advantages and limitations is essential for the acquisition of valid data in
neurological investigations. Some of the aspects presented here refer to: microelectrode insertion and positioning related
to possibilities to minimize tissue damage, spatial and temporal resolution of the measurements, actual controversies in
data interpretation and sensor calibration, simultaneous detection of multiple analytes, interferences and state of the art in
the development of wireless devices.
