Abstract
Biodegradable polymeric nanofibrosus meshes have emerged as a choice of scaffolds for cells to attach and grow as they mimic closely the nanoscale morphology of native extracellular proteins and promote cell-growth. Electrospun fibrous nanocomposite scaffolds of biodegradable synthetic polymer polycaprolactone (PCL) with surface modified carbon nanofibers (mCNFs) were successfully fabricated using the electrostatic co-spinning process. Structural and morphological properties of the nanofibrous composite scaffolds were characterized using, SEM, TEM, TGA and XRD. Microscopic analyses showed bead-free nanofibrous morphology with the presence of mCNFs in the electrospun scaffolds. The overall scaffolds’ crystallinity and degree of orientation were assessed using XRD. The mechanical properties of the electrospun scaffolds as evaluated with tensile test, showed a marked increase in strength and stiffness with nanofiber alignment and with addition of mCNFs (0.1 and 0.5 wt %). Human mesenchymal stem cells (hMSCs) cultured onto PCL/mCNFs scaffold showed successful attachment and spreading of the cells.
Keywords: Carbon nanofiber, polycaprolactone, electrospinning, nanofiber scaffolds.
Current Nanoscience
Title:Carbon Nanofiber Reinforced Polycaprolactone Fibrous Meshes by Electrostatic Co-spinning
Volume: 8 Issue: 5
Author(s): Himani D. Deshpande, Derrick R. Dean, Vinoy Thomas, William C. Clem, Moncy V. Jose, Elijah Nyairo and Manoj Mishra
Affiliation:
Keywords: Carbon nanofiber, polycaprolactone, electrospinning, nanofiber scaffolds.
Abstract: Biodegradable polymeric nanofibrosus meshes have emerged as a choice of scaffolds for cells to attach and grow as they mimic closely the nanoscale morphology of native extracellular proteins and promote cell-growth. Electrospun fibrous nanocomposite scaffolds of biodegradable synthetic polymer polycaprolactone (PCL) with surface modified carbon nanofibers (mCNFs) were successfully fabricated using the electrostatic co-spinning process. Structural and morphological properties of the nanofibrous composite scaffolds were characterized using, SEM, TEM, TGA and XRD. Microscopic analyses showed bead-free nanofibrous morphology with the presence of mCNFs in the electrospun scaffolds. The overall scaffolds’ crystallinity and degree of orientation were assessed using XRD. The mechanical properties of the electrospun scaffolds as evaluated with tensile test, showed a marked increase in strength and stiffness with nanofiber alignment and with addition of mCNFs (0.1 and 0.5 wt %). Human mesenchymal stem cells (hMSCs) cultured onto PCL/mCNFs scaffold showed successful attachment and spreading of the cells.
Export Options
About this article
Cite this article as:
D. Deshpande Himani, R. Dean Derrick, Thomas Vinoy, C. Clem William, V. Jose Moncy, Nyairo Elijah and Mishra Manoj, Carbon Nanofiber Reinforced Polycaprolactone Fibrous Meshes by Electrostatic Co-spinning, Current Nanoscience 2012; 8 (5) . https://dx.doi.org/10.2174/157341312802884409
DOI https://dx.doi.org/10.2174/157341312802884409 |
Print ISSN 1573-4137 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6786 |
Call for Papers in Thematic Issues
Role of nanomaterials in fabrication of coatings, Machining and Joining
The application of nanoscience has brought about a revolution in the field of mechanical engineering by providing novel materials, boosting manufacturing processes, and generating cutting-edge products. The purpose of this special issue is to investigate the enormous impact that nanoscience has had on mechanical engineering, with a particular emphasis on ...read more
Advanced Inorganic Nanocomposites and Their Emerging Applications
This special issue collection will highlight developments on the recent trends about the synthesis of metal oxides, nanoclusters, biomaterials, 2D nanomaterials, nanocrystals, nanocomposites, etc. and their applications in electrochemical systems, tissue regeneration, energy storage and harvesting, sensors, etc. The novelty of the methods in the chemical synthesis and their characterizations, ...read more
Applicability of Nanotechnology for Performance Enhancement of Clean Energy Technologies
Population growth, industrialization, and improvement in living quality would lead to further increase in energy demand in near future. Regarding the disadvantages of fossil fuels such as fluctuations in their price, high emissions of greenhouse gases and restriction of their sources, it is crucial to use and exploit alternative energy ...read more
Graphene and 2D Materials for Energy Storage and Conversion
This thematic issue will discuss the recent advances in graphene-based nanomaterials for different energy technologies. Graphene possesses a high surface area, and stable structure and exhibits many interesting electronic, optical, and mechanical properties due to its 2D crystal structure. Graphene is of both fundamental interest and suitable for a wide ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Epigenetic Effects of Cadmium in Cancer: Focus on Melanoma
Current Genomics KSP Inhibitors as Antimitotic Agents
Current Topics in Medicinal Chemistry Immunotherapy Resistance Mechanisms in Renal Cell Cancer
Current Signal Transduction Therapy NBN Polymorphysms and Cancer Susceptibility: A Systematic Review
Current Genomics Anticancer Properties of Asian Water Monitor Lizard (Varanus salvator), Python (Malayopython reticulatus) and Tortoise (Cuora kamaroma amboinensis)
Anti-Cancer Agents in Medicinal Chemistry The Role of Survivin for Radiation Oncology: Moving Beyond Apoptosis Inhibition
Current Medicinal Chemistry Vitamin D Metabolites and/or Analogs: Which D for Which Patient?
Current Vascular Pharmacology Undermining Tumor Angiogenesis by Gene Therapy: An Emerging Field
Current Gene Therapy Biomedical Applications of Gold Nanoparticles
Current Topics in Medicinal Chemistry MiRNA-145 and Its Direct Downstream Targets in Digestive System Cancers: A Promising Therapeutic Target
Current Pharmaceutical Design Advances in Nanomedicine Towards Clinical Application in Oncology and Immunology
Current Pharmaceutical Biotechnology The Capsaicin Paradox: Pain Relief by an Algesic Agent
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Health Benefits of Manuka Honey as an Essential Constituent for Tissue Regeneration
Current Drug Metabolism Neuro-Transmitters in the Central Nervous System & their Implication in Learning and Memory Processes
Current Medicinal Chemistry Remodelling of the Ca2+ Toolkit in Tumor Endothelium as a Crucial Responsible for the Resistance to Anticancer Therapies
Current Signal Transduction Therapy DNA Drug Design for Cancer Therapy
Current Pharmaceutical Design Olive Oil and Cancer Risk: an Update of Epidemiological Findings through 2010
Current Pharmaceutical Design Inflammation and Antiangiogenesis in Cancer
Current Medicinal Chemistry Renal Development: A Complex Process Dependent on Inductive Interaction
Current Pediatric Reviews Biological Activities of Yarrow Species (Achillea spp.)
Current Pharmaceutical Design