Many ocular surface disorders such as ocular cicatricial pemphigoid, Stevens-Johnson syndrome and chemical/
thermal burns can lead to severe ocular surface damage and scarring. The surgical approach to reconstruct the corneal
and conjunctival surface involves the excision of the scar tissue and the application of a tissue substitute. The ideal substitute
should consist of a stable, thin and elastic matrix that is well tolerated and that should ideally carry a suitable layer of
epithelium. Amniotic membrane meets many of the criteria of an ideal ocular surface substitute and is most frequently
used for ocular surface reconstruction to date. However the growing field of tissue engineering offers promising new
strategies and this article reviews new developments in matrices for ocular epithelial cell expansion for clinical applications.
Keywords: Ocular surface, limbal stem cell deficiency, cornea, conjunctiva, cell therapy, tissue engineering, keratinization, pathogenic microbes, mucocutaneous, trauma.
Rights & PermissionsPrintExport