Chemical Constituents and Bioactivities of the Plants of Genus Flemingia Roxb. et Ait. (Leguminosae)

Author(s): Hua Li, Fengyan Zhai, Zhongdong Liu

Journal Name: Combinatorial Chemistry & High Throughput Screening
Accelerated Technologies for Biotechnology, Bioassays, Medicinal Chemistry and Natural Products Research

Volume 15 , Issue 8 , 2012

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Abstract:

The genus Flemingia Roxb. et Ait. (Leguminosae) has been used for disease prevention and therapy in China since ancient times. So the material basis of the pharmacological activity in the genus Flemingia should be clear for how to use this kind of traditional Chinese medicines more reasonably in pharmacology. Therefore, this review gives an account of the current knowledge on the chemical constituents, biological activities and pharmacological properties of the plants of the genus. Several different classes of compounds were previously isolated, which the main groups are flavones, particularly prenylated flavones, and triterpenes accompanied with sterols, anthraquinones, and others. The names and structures of the chemical constituents are given in this review. In addition, the pharmacological effects of the extracts and individual compounds (mainly for flavones) derived from the genus plants have been found, including neuroprotection, anti-inflammation, anti-oxidation, cytotoxicity, hormone-like effects, antimicrobial activities, and so on.

Keywords: bioactivities, chemical constituents, genus Flemingia, prenylated flavones, Flavonols, Chalcones, Santalin flavonoids, Antibacterial, Antifungal Activity, Anti-Oxidant Activity, Cytotoxic, Anti-tumor Activity

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Article Details

VOLUME: 15
ISSUE: 8
Year: 2012
Page: [611 - 622]
Pages: 12
DOI: 10.2174/138620712802650504
Price: $65

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