Therapeutic Monitoring of Immunotherapies in Autoimmune Diseases

Author(s): Nicolas von Ahsen, Andrew Chan

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 29 , 2012

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Immunosuppressive treatment still is an important element in the management of autoimmune mediated diseases. However, immunosuppressive therapy is often complicated by a narrow therapeutic index and high variability of treatment response. This review discusses the clinical management and monitoring strategies for the use of ciclosporin A, tacrolimus, azathioprine, mycophenolat mofetil, mitoxantrone and some monoclonal antibodies with focus on natalizumab.

Keywords: Neuroimmunology, therapeutic drug monitoring, mitoxantrone, natalizumab, ciclosporin A, azathioprine, mycophenolat mofetil, immunosuppressive therapy, tacrolimus, monoclonal antibodies.

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Article Details

Year: 2012
Page: [4550 - 4555]
Pages: 6
DOI: 10.2174/138161212802502152
Price: $65

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