Abstract
Animal models have been used widely in neurology since many decades. They have led to an improved understanding of the pathophysiological processes underlying frequent diseases as multiple sclerosis or Parkinson’s disease and enabled the development of highly effective therapeutical approaches. Current developments, drawbacks and limitations of animal models in neurology are discussed with a special focus on the experimental autoimmune encephalomyelitis – model of multiple sclerosis.
Keywords: Animal models, neurology, multiple sclerosis, encephalitogenic epitopes, experimental autoimmune encephalomyelitis, microarray, transgene animals, natalizumab, Parkinson’s disease, conditioned reflex.
Current Pharmaceutical Design
Title:Animal Models in Neurology: Drawbacks and Opportunities
Volume: 18 Issue: 29
Author(s): Robert Patejdl and Uwe K. Zettl
Affiliation:
Keywords: Animal models, neurology, multiple sclerosis, encephalitogenic epitopes, experimental autoimmune encephalomyelitis, microarray, transgene animals, natalizumab, Parkinson’s disease, conditioned reflex.
Abstract: Animal models have been used widely in neurology since many decades. They have led to an improved understanding of the pathophysiological processes underlying frequent diseases as multiple sclerosis or Parkinson’s disease and enabled the development of highly effective therapeutical approaches. Current developments, drawbacks and limitations of animal models in neurology are discussed with a special focus on the experimental autoimmune encephalomyelitis – model of multiple sclerosis.
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Cite this article as:
Patejdl Robert and K. Zettl Uwe, Animal Models in Neurology: Drawbacks and Opportunities, Current Pharmaceutical Design 2012; 18 (29) . https://dx.doi.org/10.2174/138161212802502233
DOI https://dx.doi.org/10.2174/138161212802502233 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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