Apoptosis Signalling Activated by TNF in the Lower Gastrointestinal Tract-Review

Author(s): Natalya Benderska, Saritha Chakilam, Manuela Hugle, Jelena Ivanovska, Muktheshwar Gandesiri, Jan Schulze-Luhrmann, Khuloud Bajbouj, Ronald Croner, Regine Schneider-Stock

Journal Name: Current Pharmaceutical Biotechnology

Volume 13 , Issue 11 , 2012

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The tumor necrosis factor (TNF) gene is an immediate early gene, rapidly transcribed in a variety of cell types following exposure to a broad range of pathogens and signals of inflammation and stress. Regulation of TNF gene expression at the transcriptional level is cell type- and stimulus-specific, involving epigenetic mechanisms or miRNAs. A better knowledge of the molecular mechanisms that control TNF gene regulation and TNF signalling will provide deeper understanding of the initiation and development of apoptotic and inflammatory processes triggered by TNF cytokine in the gut. The described efforts to embed TNF in clinical treatment regiments reflect its attractive effectiveness in killing tumor cells. Whether the described strategies will achieve the success of incorporating TNF in lower gastrointestinal tract therapy for inflammatory diseases and cancer remains to be determined.

Keywords: TNF signalling, apoptosis, colorectal tumor cells, radiotherapy, intestinal epithelial cells, immune cells, tumor necrosis factor (TNF), cancer, Apoptosis, cytotoxic therapy

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Article Details

Year: 2012
Page: [2248 - 2258]
Pages: 11
DOI: 10.2174/138920112802501971
Price: $65

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