The Hypothalamic-Neurohypophyseal System: Current and Future Treatment of Vasopressin and Oxytocyn Related Disorders

Author(s): Rocco S.Calabro, Domenico Italiano, Danilo Ferrara, Stefania Mondello, Valeria Conti-Nibali, Carlo Salviera, Placido Bramanti

Journal Name: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery (Discontinued)

Volume 6 , Issue 3 , 2012


The hypothalamus and posterior pituitary form a complex neurohumoral system playing a key role in maintaining body fluid homeostasis and reproductive function. We review the pathophysiology mechanisms of posterior pituitary hormones and their implications, beyond water balance and delivery, in social functioning, pair bonding and affiliative behavior. Actual and future treatments for neurohypophysis related disorders are also discussed, particularly focusing on the development of new therapeutic compounds and patents.

Keywords: Hypothalamus, neurohypophysis, oxytocin, pituitary, treatment, vasopressin.

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Article Details

Year: 2012
Page: [235 - 250]
Pages: 16
DOI: 10.2174/187221412802481720
Price: $58

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