Various aminopeptidases belong to the M1 aminopeptidase family. They are all zinc dependent enzymes playing
important roles in several biological processes such as regulation of blood pressure under both physiological and
pathological conditions, and the angiogenesis and metastasis of tumor, etc. They all have the highly conserved
HEXXH(X)18E zinc-binding and GAMEN motifs essential for enzyme activities. In this review, the current situation regarding
the biochemical characteristics, biological functions and inhibitors of three important members of these enzymes,
aminopeptidase A, aminopeptidase N and aminopeptidase B are summarized.
Keywords: aminopeptidase A, aminopeptidase B, aminopeptidase N, renin–angiotensin system, hypertension, angiogenesis,
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