Various encapsulation approaches have been explored during the last years in order to encapsulate classical active
molecules and new synthesized molecules principally for the in vivo therapy as drug delivery nanocarriers and also
for the in vivo biomedical diagnostic. These approaches lead to new and versatile systems exhibiting high encapsulation
yields of small molecules mainly. Due to the use of biodegradable polymers, the final particles and dispersions exhibit
low cytotoxicity and in some cases total biocompatibility. To enhance local targeting efficiency, nanoparticles are chemically
grafted using specific antibody for a specific disease. One of the easiest processes leading to rapid particles formation
is the nanoprecipitation. Such process is mainly based on polymer transfer from good solvent to poor solvent condition,
leading consequently to nanoparticles formation via self-assembly of precipitated polymer chains. The article discussed
some of patents associated with Nanoprecipitation Process.
Keywords: Active molecule protection, controlled drug release, nanoprecipitation, preformed polymer, polymer-based
nanoparticles, POLYMER PRECIPITATION, NON-LOADED NANOPARTICLE SUSPENSION, COSMETIC USE, cutaneous applications, transdermal transport.
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Published on: 05 August, 2012
Page: [250 - 258]