Title:Single Emulsion-Solvent Evaporation Technique and Modifications for the Preparation of Pharmaceutical Polymeric Nanoparticles
VOLUME: 6 ISSUE: 3
Author(s):Maria G. Nava-Arzaluz, Elizabeth Pinon-Segundo, Adriana Ganem-Rondero and David Lechuga-Ballesteros
Affiliation:Laboratorio de Investigacion y Posgrado en Tecnologia Farmaceutica, Facultad de Estudios Superiores Cuautitlan, Universidad Nacional Autonoma de Mexico. Av 1º de Mayo s/n, Col. Santa Maria las Torres, Cuautitlan Izcalli, Estado de Mexico, 54740, Mexico.
Keywords:Drug delivery, hydrophilic drugs, polymeric nanoparticles, preformed polymers, poorly soluble drugs, single emulsion,
solvent evaporation, surface modifications, solvent toxicity, SESEM.
Abstract:In recent years, there has been an increased interest in using nanoparticles for drug delivery and pharmaceutical
development. Nanoparticles can offer significant advantages over the conventional drug delivery systems in terms of high
drug loading, stability and specificity, controlled release capability, and the ability to deliver both hydrophilic and hydrophobic
drug molecules through various routes of administration. This review article focuses on the use of the single emulsion
solvent evaporation method, the first method proposed for the preparation of polymeric nanoparticles, and modifications
that have been developed over the years to improve the results obtained with this technique.
