Emerging RNA-based Drugs: siRNAs, microRNAs and Derivates

Author(s): Tiago Campos Pereira, Iscia Lopes-Cendes

Journal Name: Central Nervous System Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Central Nervous System Agents

Volume 12 , Issue 3 , 2012

Become EABM
Become Reviewer
Call for Editor


An emerging new category of therapeutic agents based on ribonucleic acid has emerged and shown very promising in vitro, animal and pre-clinical results, known as small interfering RNAs (siRNAs), microRNAs mimics (miRNA mimics) and their derivates. siRNAs are small RNA molecules that promote potent and specific silencing of mutant, exogenous or aberrant genes through a mechanism known as RNA interference. These agents have called special attention to medicine since they have been used to experimentally treat a series of neurological conditions with distinct etiologies such as prion, viral, bacterial, fungal, genetic disorders and others. siRNAs have also been tested in other scenarios such as: control of anxiety, alcohol consumption, drug-receptor blockage and inhibition of pain signaling. Although in a much earlier stage, miRNAs mimics, anti-miRs and small activating RNAs (saRNAs) also promise novel therapeutic approaches to control gene expression. In this review we intend to introduce clinicians and medical researchers to the most recent advances in the world of siRNA- and miRNA-mediated gene control, its history, applications in cells, animals and humans, delivery methods (an yet unsolved hurdle), current status and possible applications in future clinical practice.

Keywords: Anti-miRs, dsRNA, microRNA, RNA drugs, RNA interference, siRNA, Abn-CBD receptor, anti-inflammatory.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [217 - 232]
Pages: 16
DOI: 10.2174/187152412802430138
Price: $65

Article Metrics

PDF: 42