Abstract
Mounting evidence points to dietary habits as an important determinant of health/disease prevention. Although the linkages with diet are intriguing, the literature is also laden with many inconsistencies. The reasons for these inconsistencies are likely multi-factorial, but probably reflect variation in the ability of bioactive constituents to reach or to influence a specific and critical molecular target(s). Knowledge about three types of biomarkers will assist in comparing the effectiveness of foods and drugs: (1) exposure (amount and time needed to bring about a response), (2) effect (amounts and activity of specific molecular target[s]) and (3) susceptibility determinants (agent-gene interactions or diet-drug interactions). As the era of molecular nutrition unfolds, a greater understanding of how foods and their components influence normal cellular process and ultimately health will surely arise. Knowledge about the molecular targets for bioactive food components may also help explain individuality in response to drugs. Such information will be critical in the development of effective tailored strategies for optimizing health.
Keywords: Dietary, drugs, foods, genes, health, nutrigenomics, targets, omega-3, prebiotic, probiotic
Current Pediatric Reviews
Title:Common Molecular Targets for Bioactive Food Components and Drugs
Volume: 8 Issue: 3
Author(s): John A. Milner
Affiliation:
Keywords: Dietary, drugs, foods, genes, health, nutrigenomics, targets, omega-3, prebiotic, probiotic
Abstract: Mounting evidence points to dietary habits as an important determinant of health/disease prevention. Although the linkages with diet are intriguing, the literature is also laden with many inconsistencies. The reasons for these inconsistencies are likely multi-factorial, but probably reflect variation in the ability of bioactive constituents to reach or to influence a specific and critical molecular target(s). Knowledge about three types of biomarkers will assist in comparing the effectiveness of foods and drugs: (1) exposure (amount and time needed to bring about a response), (2) effect (amounts and activity of specific molecular target[s]) and (3) susceptibility determinants (agent-gene interactions or diet-drug interactions). As the era of molecular nutrition unfolds, a greater understanding of how foods and their components influence normal cellular process and ultimately health will surely arise. Knowledge about the molecular targets for bioactive food components may also help explain individuality in response to drugs. Such information will be critical in the development of effective tailored strategies for optimizing health.
Export Options
About this article
Cite this article as:
A. Milner John, Common Molecular Targets for Bioactive Food Components and Drugs, Current Pediatric Reviews 2012; 8 (3) . https://dx.doi.org/10.2174/157339612802139424
DOI https://dx.doi.org/10.2174/157339612802139424 |
Print ISSN 1573-3963 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6336 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Primary and Secondary Insomnia: Prevalence, Causes and Current Therapeutics
Current Medicinal Chemistry - Central Nervous System Agents Psychoemotional Background of Temporomandibular Joint Dysfunction and Possible Drug Therapy
Letters in Drug Design & Discovery LINE-1 Methylation is Associated with an Increased Risk of Ischemic Stroke in Men
Current Neurovascular Research Evaluating the Efficacy of Intra-articular Injections of Platelet Rich Plasma (PRP) in Rheumatoid Arthritis Patients and its Impact on Inflammatory Cytokines, Disease Activity and Quality of Life
Current Rheumatology Reviews A Review of Flavonoids from Cassia Species and their Biological Activity
Current Pharmaceutical Biotechnology New Analytical Tools for Studying Autoimmune Diseases
Current Pharmaceutical Design Rheumatologic Aspects of the COVID-19 Pandemic: A Practical Resource for Physicians in Kuwait and the Gulf region as Recommended by the Kuwait Association of Rheumatology
Current Rheumatology Reviews Rheumatoid Arthritis: An Evolutionary Force in Biologics
Current Pharmaceutical Design Atherogenic Index of Plasma in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus: A 10-Year Potential Predictor of Cardiovascular Disease
Current Rheumatology Reviews Drug Metabolism and Pharmacokinetic Diversity of Ranunculaceae Medicinal Compounds
Current Drug Metabolism Resistant Hypertension in the Elderly-Second Line Treatments: Aldosterone Antagonists, Central Alpha-Agonist Agents, Alpha-Adrenergic Receptor Blockers, Direct Vasodilators, and Exogenous Nitric Oxide Donors
Cardiovascular & Hematological Agents in Medicinal Chemistry Real-Time 3D Echocardiography: A New Gold Standard for Rheumatic Mitral Stenosis Assessment
Current Cardiology Reviews Pulmonary Manifestations of Rheumatoid Arthritis, Psoriatic Arthritis and Peripheral Spondyloarthritis: Prevalence, Diagnostic Approach and Treatment Options
Current Rheumatology Reviews Anti-inflammatory Property of AMP-activated Protein Kinase
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry Assessment of Possible Drug Interactions in Patients with Psoriasis and Associated Comorbid Medical Conditions: An Observational Study
Reviews on Recent Clinical Trials <i>Momordica balsamina L</i>.: An Appraisal on Morphology, Ecological Diversity, Phytochemistry, Pharmacological and Biotechnological Applications
Current Traditional Medicine Biologic Agents for Treatment of Rheumatoid Arthritis
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry The Modification of Serum Lipids after Acute Coronary Syndrome and Importance in Clinical Practice
Current Cardiology Reviews Postoperative Atrial Fibrillation - What Do We Really Know?
Current Vascular Pharmacology Persistent Clinical Response of Infliximab Therapy in Patients with Refractory Rheumatoid Arthritis, over a 3-Year Period
Current Clinical Pharmacology