Matrix Metalloproteinase Dependent Cleavage of Cell Adhesion Molecules in the Pathogenesis of CNS Dysfunction with HIV and Methamphetamine

Author(s): Katherine Conant, Seung T. Lim, Brad Randall, Kathleen A. Maguire-Zeiss

Journal Name: Current HIV Research

Volume 10 , Issue 5 , 2012

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Physiologically appropriate levels of matrix metalloproteinases (MMPs) are likely important to varied aspects of CNS function. In particular, these enzymes may contribute to neuronal activity dependent synaptic plasticity and to cell mobility in processes including stem cell migration and immune surveillance. Levels of MMPs may, however, be substantially increased in the setting of HIV infection with methamphetamine abuse. Elevated MMP levels might in turn influence integrity of the blood brain barrier, as has been demonstrated in published work. Herein we suggest that elevated levels of MMPs can also contribute to microglial activation as well as neuronal and synaptic injury through a mechanism that involves cleavage of specific cell and synaptic adhesion molecules.

Keywords: Matrix metalloproteinase (MMP), synapse, neuron, microglial cell, adhesion, cell adhesion molecule (CAM), methamphetamine, CNS, HAND, SNARE.

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Article Details

Year: 2012
Page: [384 - 391]
Pages: 8
DOI: 10.2174/157016212802138733
Price: $65

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