Title:Palladacycles as Antimicrobial Agents
VOLUME: 19 ISSUE: 23
Author(s):A. -S.S.H. Elgazwy, N. S.M. Ismail, S. R. Atta-Allah, M. T. Sarg, D. H.S. Soliman, M. Y. Zaki and M. A. Elgamas
Affiliation:Department of Chemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Keywords:Palladacycles, organopalladium complexes, anti-bacterial, anti-fungal, anti-mycobacterial, antiprotozoal, anti-trypanosomal, antiamoebic, palladium, nitrogen
Abstract:This review article deals with the structure activity relationship (SAR) for a variety of palladacycles in biomedical
applications. Moreover, the types of antibacterial, antifungal, antimycobacterial and antiprotozoal (antiamoebic and antitrypanosomal)
activities will vary considerably from one country to another. Therefore, all efforts will be required to face such a vast diversity of
problems. This study gives an up to date overview of the antibacterial, antifungal, antimycobacterial and antiprotozoal chemistry of the
palladium group elements with an emphasis on the new strategies used in the development of new antibacterial agents. Methodologies for
application of bulky aromatic or aliphatic nitrogen ligands, chiral organic moieties, chelates containing other donor atoms than nitrogen,
and biologically active ligands in the design of agents analogous to palladacycles are presented. Therefore, the use of palladacycles in
medicinal chemistry is interesting as potential application in the biological properties with less toxic drugs compounds..
