Title:Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments
VOLUME: 19 ISSUE: 23
Author(s):A. Banerjee and O. Prante
Affiliation:Laboratory of Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich-Alexander University, Schwabachanlage 6, D-91054 Erlangen, Germany.
Keywords:Dopamine, D2, D3, D4, dopamine receptor, selectivity, subtype-selectivity, positron emission tomography, PET, radioligand, PET ligand, radiopharmaceutical, F-18, C-11
Abstract:This review presents a general overview of the subtype-selective dopamine receptor radioligands for in vivo imaging of
dopamine receptor expression by positron emission tomography (PET). Besides the 11C- and 18F-labeled radioligands which are already
in clinical use, a summary of subtype-selective radioligands which had been studied in vitro and in vivo is provided, which shines light
onto the current status and recent developments in this field of radiopharmaceutical research.
