Title:TRAIL as Biomarker and Potential Therapeutic Tool for Cardiovascular Diseases
VOLUME: 13 ISSUE: 9
Author(s):Stella Bernardi, Daniela Milani, Bruno Fabris, Paola Secchiero and Giorgio Zauli
Affiliation:Institute for Maternal and Child Health, IRCCS Burlo Garofolo of Trieste Via dell’Istria 65/1, 34138 Trieste, Italy.
Keywords:Cardiovascular diseases, diabetes, TRAIL, Apo2 ligand, TNF, cellular apoptosis, OPG, coronary artery disease, biomarkers, soluble protein
Abstract:This review focuses on TNF-related apoptosis-inducing ligand (TRAIL), also called Apo2 ligand, a protein belonging
to the TNF superfamily. TRAIL can be found either in its transmembrane or circulating form, and its mostly studied
peripheral effect is the induction of cellular apoptosis. Here, we discuss the evidences supporting the use of TRAIL as
biomarker of cardiovascular diseases as well as the evidences showing the potential beneficial therapeutic effects of
TRAIL on cardiovascular diseases and diabetes.
