On the Role of Endothelial TRPC3 Channels in Endothelial Dysfunction and Cardiovascular Disease

Author(s): K. Smedlund, M. Bah, G. Vazquez

Journal Name: Cardiovascular & Hematological Agents in Medicinal Chemistry
Formerly Current Medicinal Chemistry - Cardiovascular & Hematological Agents

Volume 10 , Issue 3 , 2012

Become EABM
Become Reviewer
Call for Editor


In endothelium, calcium (Ca2+) influx through plasma membrane Ca2+-permeable channels plays a fundamental role in several physiological functions and in the pathogenesis of cardiovascular disease. Current knowledge on the influence of Ca2+ influx in signaling events associated to endothelial dysfunction has grown significantly over recent years, particularly after identification of members of the Transient Receptor Potential Canonical (TRPC) family of channel forming proteins as prominent mediators of Ca2+ entry in endothelial cells. Among TRPC members TRPC3 has been at the center of many of these physiopathological processes. Progress in elucidating the mechanism/s underlying regulation of endothelial TRPC3 and characterization of signaling events downstream TRPC3 activation are of most importance to fully appreciate the role of this peculiar cation channel in cardiovascular disease and its potential use as a therapeutic target. In this updated review we focus on TRPC3 channels, revising and discussing current knowledge on channel expression and regulation in endothelium and the roles of TRPC3 in cardiovascular disease in relation to endothelial dysfunction.

Keywords: atherosclerosis, Ca2+ influx, calcium signaling, cardiovascular disease, cation channels, endothelial dysfunction, TRPC3 channels, vascular endothelium, vascular inflammation

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Published on: 17 July, 2012
Page: [265 - 274]
Pages: 10
DOI: 10.2174/187152512802651051
Price: $65

Article Metrics

PDF: 12