Novel Concepts for Organic Syntheses Based on Interfaces and Molecular Machines

Author(s): Shinsuke Ishihara, Yutaka Wakayama, Nobuya Hiroshiba, Jonathan P. Hill, Katsuhiko Ariga

Journal Name: Current Organic Synthesis

Volume 9 , Issue 4 , 2012


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Abstract:

Without doubt, organic chemistry has made significant contributions in improving the qualities of our lives. However, there exists a demand for well-designed molecules of complex structures with additional requirements for low-cost and low-energy production of the materials, which stimulate us to consider innovative concepts in organic synthetic methods. In order to propose innovative methods for next-generation organic synthetic procedures, we present two strategies, (i) organic synthesis within two-dimensional molecular patterns and (ii) organic synthesis driven by molecular machines working at interfaces. For example, synthesis of stereo-regulated polymeric materials in two-dimensional molecular arrays, tip-induced chemical reactions at a solid surface, sequential reactions guided by polymer chains, DNA-nanorobots on two-dimensional DNA origami, ester hydrolysis based on modified behavior of protonated amines at an interface, and several other methods are introduced as pioneering and innovative concepts.

Keywords: Interface, DNA Origami, Molecular Machine, Molecular Recognition, Molecular Pattern, Surface, DNA-nanorobots, optimization.

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Article Details

VOLUME: 9
ISSUE: 4
Year: 2012
Page: [428 - 438]
Pages: 11
DOI: 10.2174/157017912802651384
Price: $65

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