Abstract
Doping with erythropoietic proteins such as erythropoietin (EPO) is a serious issue in sport. There is little information on the possible ophthalmologic alterations followed by frequent EPO abuse in athletes. EPO is a potent retinal angiogenic factor and is capable of stimulating retinal angiogenesis and neovascularization in the presence of ischemia. Systemic and intravitreal EPO concentrations are highly correlated. A linkage between EPO doping and retinal proliferation is possible and further studies are warranted. Gathering and analyzing data on retinal findings from these athletes, either retrospectively or prospectively might yield preliminary information to support the safety of those athletes. Implications of this hypothesis cover other kinds of neovascularizations and angiogenesis.
Keywords: Erythropoietin, doping, retinal neovasularization, angiogenesis.
Current Drug Safety
Title:Possibility of Enhanced Risk of Retinal Angiogenesis in Athletes with Pre- Existing Retinal Situation Abusing Erythropoietin Doping: A Hypothesis
Volume: 7 Issue: 2
Author(s): Reza Rastmanesh
Affiliation:
Keywords: Erythropoietin, doping, retinal neovasularization, angiogenesis.
Abstract: Doping with erythropoietic proteins such as erythropoietin (EPO) is a serious issue in sport. There is little information on the possible ophthalmologic alterations followed by frequent EPO abuse in athletes. EPO is a potent retinal angiogenic factor and is capable of stimulating retinal angiogenesis and neovascularization in the presence of ischemia. Systemic and intravitreal EPO concentrations are highly correlated. A linkage between EPO doping and retinal proliferation is possible and further studies are warranted. Gathering and analyzing data on retinal findings from these athletes, either retrospectively or prospectively might yield preliminary information to support the safety of those athletes. Implications of this hypothesis cover other kinds of neovascularizations and angiogenesis.
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Cite this article as:
Rastmanesh Reza, Possibility of Enhanced Risk of Retinal Angiogenesis in Athletes with Pre- Existing Retinal Situation Abusing Erythropoietin Doping: A Hypothesis, Current Drug Safety 2012; 7 (2) . https://dx.doi.org/10.2174/157488612802715708
DOI https://dx.doi.org/10.2174/157488612802715708 |
Print ISSN 1574-8863 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3911 |
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