Dendrimers have found extensive convention in varied fields of biomedical engineering. Particularly, polyamidoamine
(PAMAM) dendrimers have been found to have unique properties, and also interesting researches in the field of
biomedical engineering have been recognized, when compared to other class of dendrimers. PAMAM dendrimers are biofriendly
synthetic substances, and broadly studied dendrimers for biomedical applications, especially as therapeutic compositions.
The focus of this review (citing 188 references) is on PAMAM dendrimer developments for biomedical applications,
with prominence on conjugations for their extensive applications in the field of biomedical engineering and comparisons
between classical (Tomalia PAMAM dendrimers) and novel (Baker-Huang PAMAM dendrimers) PAMAM dendrimers
are also discussed by covering recent patents on PAMAM dendrimers. Finally, the use of PAMAM dendrimers in
the field of proteomics, especially for use in phosphopeptide enrichment is presented. The future work points at the promises
Keywords: Patents, PAMAM dendrimers, PAMAM dendrimer-compositions, PAMAM dendrimer-conjugations, biomedical
applications, disease-specific, Synthetic Strategies, Pharmacokinetics, biomacromolecules, Cytotoxicity.
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Published on: 15 July, 2012
Page: [159 - 174]