Abstract
Descending necrotizing mediastinitis is an acute, polymicrobial infection. Originating in the pharynx or neck, this necrotizing process descends into the chest producing widespread tissue necrosis. Despite the introduction of modern antimicrobial therapy and computed tomographic imaging, this form of mediastinitis has continued to produce reported mortality rates of 25% to 40%. This review discusses the pathophysiology, diagnosis and treatment of descending necrotizing mediastinitis with recommendations for treating physicians based on the modern literature.
Keywords: Descending, mediastinitis, necrotizing, polymicrobial infection, tissue necrosis, PATHOPHYSIOLOGY, cervicofascial infection, computed tomographic imaging, chest roentgenograms, modern.
Current Respiratory Medicine Reviews
Title:Descending Necrotizing Mediastinitis: Current Strategies for Diagnosis and Treatment
Volume: 8 Issue: 4
Author(s): Richard K. Freeman, Theresa Giannini, Amy Vyverberg and Anthony J. Ascioti
Affiliation:
Keywords: Descending, mediastinitis, necrotizing, polymicrobial infection, tissue necrosis, PATHOPHYSIOLOGY, cervicofascial infection, computed tomographic imaging, chest roentgenograms, modern.
Abstract: Descending necrotizing mediastinitis is an acute, polymicrobial infection. Originating in the pharynx or neck, this necrotizing process descends into the chest producing widespread tissue necrosis. Despite the introduction of modern antimicrobial therapy and computed tomographic imaging, this form of mediastinitis has continued to produce reported mortality rates of 25% to 40%. This review discusses the pathophysiology, diagnosis and treatment of descending necrotizing mediastinitis with recommendations for treating physicians based on the modern literature.
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Cite this article as:
K. Freeman Richard, Giannini Theresa, Vyverberg Amy and J. Ascioti Anthony, Descending Necrotizing Mediastinitis: Current Strategies for Diagnosis and Treatment, Current Respiratory Medicine Reviews 2012; 8 (4) . https://dx.doi.org/10.2174/157339812802652224
DOI https://dx.doi.org/10.2174/157339812802652224 |
Print ISSN 1573-398X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6387 |
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