Therapeutic Potential and Strategies Against Leukocyte-Platelet Interaction in Atherosclerosis

Author(s): Peter Seizer, Andreas E. May

Journal Name: Current Vascular Pharmacology

Volume 10 , Issue 5 , 2012

Become EABM
Become Reviewer
Call for Editor


Leukocyte rolling, adhesion, transmigration and activation are features of vascular inflammation leading to atherosclerosis. In particular the interaction between platelets and leukocytes is a key process for adhesion of inflammatory cells to the vascular wall. The various mechanisms of the specific platelet-leukocyte interaction may provide a powerful target to prevent initiation and/or progression of atherosclerotic lesions.

Keywords: Atherosclerosis, EMMPRIN, monocytes, platelets, pharmacological inhibition, inflammation, P-Selectin, clopidogrel, cytokines, chemokines

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2012
Page: [550 - 554]
Pages: 5
DOI: 10.2174/157016112801784585
Price: $65

Article Metrics

PDF: 7