Tumor necrosis factor-α (TNF-α) is a major cytokine involved in the inflammatory response. Elevated TNF-α
expression has been found to be associated with the development of diabetes, septic shock, tumorigenesis, cardiovascular
diseases, rheumatoid arthritis and inflammatory bowel disease. In the past decade, the success of anti-TNF-α biologics has
valuated the importance of the blockade of TNF-α production in the treatment of patients with various inflammatory diseases.
Oxidative stress is another important element in oxidative/inflammatory responses that directly linked to oxidation
of proteins, DNA and lipids. The increased oxidant levels could activate nuclear factor-kappaB (NFκ-B), signal transduction
and gene expression of TNF-α, interleukin-1 (IL-1) and other pro-inflammatory cytokines. Therefore, TNF-α inhibitors
with anti-oxidative stress activity may have multiple target effect that could exhibit excellent anti-inflammatory activities.
The review briefly highlights the pathological roles of TNF-α and oxidative stress in inflammation, and covers
those natural products as TNF-α inhibitors capable of anti-oxidative stress activity.
Keywords: TNF-α inhibitors, anti-oxidative stress, natural products, diabetes, septic shock, tumorigenesis, cardiovasculardiseases, rheumatoid arthritis, inflammatory bowel disease, anti-TNF-α biologics, TNF-α production, Oxidative stress
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