Studies on the post-transcriptional control of gene expression in hematopoietic cells have uncovered that a subfamily
of heterogeneous nuclear ribonucleoproteins (hnRNPs) is involved in cytoplasmic gene regulation. Among them
hnRNP K and hnRNPs E1/E2 share common structural motifs, the hnRNP K homology (KH) domains that provide a
functional basis for RNA binding. Specific sub-cellular localization and differentiation dependent post-translational modifications
modulate the interaction of these proteins with mRNA and proteins in messenger ribonucleoprotein complexes
(mRNPs), the latter generating connectivity to cell signaling events. As components of different mRNPs, hnRNP K and
hnRNPs E1/E2 function as crucial modulators of mRNA stability and translation in hematopoietic cell differentiation.
Keywords: Erythropoiesis, hnRNP K, hnRNP E1, hnRNP E2, mRNA stability, mRNA translation, myeloid differentiation, RNA synthesis, hnRNP, RNA recognition.
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Published on: 01 July, 2012
Page: [391 - 400]