A growing body of work demonstrates the importance of post-transcriptional control, in particular translation
initiation, in the overall regulation of gene expression. Here we focus on the contribution of regulatory elements within the
5’ and 3’ untranslated regions of mRNA to gene expression in eukaryotic cells including terminal oligopyrimidine tracts,
internal ribosome entry segments, upstream open reading frames and cytoplasmic polyadenylation elements. These
mRNA regulatory elements may adopt complex secondary structures and/or contain sequence motifs that allow their interaction
with a variety of regulatory proteins, RNAs and RNA binding proteins, particularly hnRNPs. The resulting interactions
are context-sensitive, and provide cells with a sensitive and fast response to cellular signals such as hormone exposure
or cytotoxic stress. Importantly, an increasing number of diseases have been identified, particularly cancers and
those associated with neurodegeneration, which originate either from mutation of these regulatory motifs, or from deregulation
of their cognate binding partners.
Keywords: Translation, 5’ untranslated region, IRES, uORF, TOP, polyA tail, 4EBPs, Anne E Willis, UTRs, OLIGOPYRIMIDINE.
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Published on: 01 July, 2012
Page: [294 - 304]