Title:PEG-Mediated Catalyst-Free Expeditious Synthesis of Polysubstituted Anilines and Benzenes via the Reaction of Malononitrile and β-Ketoester Derivatives in the Presence of Activated Acetylenes
VOLUME: 15 ISSUE: 7
Author(s):Mohammad Piltan, Loghman Moradi, Hiwa Salimi, Kiomars Zargoosh and Seyed Amir Zarei
Affiliation:Department of Chemistry, Sanandaj Branch, Islamic Azad University, Sanandaj, Iran.
Keywords:Activated acetylenes, functionalized anilines and benzenes, malononitrile, PEG, β-ketoester, green chemistry, Catalyst-Free, solvent-free techniques, Aromatic amines, cyanoanilines
Abstract:Poly(ethylene glycol) (PEG) has been used as a sustainable, non-volatile, and environmentally friendly reaction
solvent for synthesis of functionalized anilines and benzenes via the reaction of malononitrile and β-ketoester derivatives
in the presence of activated acetylenes at 80o C. No additional solvent and catalyst are required.
