Biological Models Volume Title: From Knowledge Networks to Biological Models

Biological Models Volume Title: From Knowledge Networks to Biological Models

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Most findings about molecular interactions and cellular regulatory events are published in peer-reviewed scientific literature in the form of scientific jargon. The computerized text-mining ...
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Mechanism of Synergistic Carcinogenesis from Hypergastrinemia and Helicobacter Infection

Pp. 131-150 (20)

Anton Yuryev

Abstract

We have built a model for gastric cancer predisposition caused by hypergastrenimia during Helicobacter infection. The model was built using publically available data form hypergastrenimic transgenic mice infected with Helicobacter. We used the model to identify potential drug targets for gastric cancer, annexin II and TRAF6, and to find prognostic biomarkers for gastric cancer predisposition due to hypergastrenimia.

Keywords:

Bioinformatics, pathway analysis, biomarkers, mechanistic model, gastric cancer, stomach cancer, Helicobacter, gene expression microarray, subnetwork enrichment analysis, NF-kappaB, annexin, gastrin, Pathway Studio.

Affiliation:

Ariadne Genomics Inc., Rockville, MD, USA