Search Result "off-target"


Morpholino, siRNA, and S-DNA Compared: Impact of Structure and Mechanism of Action on Off-Target Effects and Sequence Specificity

Journal: Current Topics in Medicinal Chemistry
Volume: 7 Issue: 7 Year: 2007 Page: 651-660
Author(s): James E. Summerton

Mechanisms of Action of DNA-Damaging Anticancer Drugs in Treatment of Carcinomas: Is Acute Apoptosis an “Off-Target” Effect?

Journal: Mini-Reviews in Medicinal Chemistry
Volume: 7 Issue: 1 Year: 2007 Page: 1035-1039
Author(s): Aleksandra Mandic Havelka, Maria Berndtsson, Maria Hagg Olofsson, Maria C. Shoshan, Stig Linder

The Relative Transcription Index: A Gene Expression Based Metric for Prioritization of Drug Candidates

Journal: Combinatorial Chemistry & High Throughput Screening
Volume: 10 Issue: 4 Year: 2007 Page: 239-245
Author(s): Sujoy Ghosh, Mike A. Watson, Jon L. Collins

A Review of Recent Patents Concerning Therapy of Respiratory Diseases Using Gene Silencing by RNAi (RISC) and EGS (RNAse P)

Journal: Recent Patents on Inflammation & Allergy Drug Discovery
Volume: 1 Issue: 1 Year: 2007 Page: 49-55
Author(s): David H. Dreyfus, Lucy Ghoda

Development of Ribozyme-Based Gene-Inactivations; The Example of the Hepatitis Delta Virus Ribozyme

Journal: Current Gene Therapy
Volume: 7 Issue: 3 Year: 2007 Page: 205-216
Author(s): M. Asif-Ullah, Michel Levesque, Gilles Robichaud, Jean-Pierre Perreault

Therapeutic Utilisations of Vasopressin and Oxytocin in Mood Disorders

Journal: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Volume: 1 Issue: 2 Year: 2007 Page: 157-161
Author(s): Gabrielle Scantamburlo, William Pitchot, Emmanuel Pinto, Marc Ansseau, Jean-Jacques Legros

Designing Drugs on the Internet? Free Web Tools and Services Supporting Medicinal Chemistry

Journal: Current Topics in Medicinal Chemistry
Volume: 7 Issue: 1 Year: 2007 Page: 1491-1501
Author(s): Peter Ertl, Stephen Jelfs

Adalimumab

Journal: Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Volume: 6 Issue: 3 Year: 2007 Page: 217-227
Author(s): Meltem Uslu

Molecular Approaches to Cervical Cancer Therapy

Journal: Current Drug Discovery Technologies
Volume: 4 Issue: 3 Year: 2007 Page: 208-219
Author(s): Luis M. Alvarez-Salas, Joseph A. DiPaolo, Luis M. Alvarez-Salas, Joseph A. DiPaolo

Recent Developments in Particulate-Based Vaccines

Journal: Recent Patents on Drug Delivery & Formulation
Volume: 1 Issue: 2 Year: 2007 Page: 117-129
Author(s): Yvonne Perrie, Daniel Kirby, Vincent W. Bramwell, Afzal R. Mohammed

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