Abstract
The exact cause of Alzheimer ’ s disease is still unknown; despite the dramatic progress in understanding. Most gene mutations associated with Alzheimer's disease point to the amyloid precursor protein and amyloid β. The α-, β- and γ-secretases execute the amyloid precursor protein processing. Significant progress has been made in the selective inhibition and modulation of these proteases, regardless of the availability of structural information. Peptidic and nonpeptidic leads were identified and several drug candidates are 2008 in clinical trials. Successful trials demand either large cohorts or reliable biological surrogate markers for Alzheimer's disease. Therefore, several radio markers are under investigation to support such clinical trials by PET-imaging. Here we summarize the developments until 2006 and highlight the important developments until 2008.
Keywords: Alzheimer's disease, secretase, copper, aspartic protease, cholesterol, imaging
Related Journals
Current Chinese Science
Anti-Cancer Agents in Medicinal Chemistry
Current Computer-Aided Drug Design
Current Bioactive Compounds
Current Medicinal Chemistry
Current Topics in Chemistry
The Natural Products Journal
Current Catalysis
Current Chinese Chemistry
Combinatorial Chemistry & High Throughput Screening
Related Books
A Journey Through Water: A Scientific Exploration of The Most Anomalous Liquid on Earth
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications
Advances in Mathematical Chemistry and Applications Volume 1 (Revised Edition)
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis
Advances in Organic Synthesis