Skin Cancer as an Emerging Global Threat and Potential Natural Therapeutic

Background and Aim: Global advancement is facing a huge threat due to the increased number of skin cancer cases and potential health-system costs. Perception of skin cancer prevalence is important for the treatment, prevention strategies, and administration of medical allowances. In addition to fair and tanned skin, the risk factor for the development of disease is sedentary lifestyle habits, and the reduction in physical activities has risen the mortalities worldwide. This effort signifies information on incidence, risk factors, and mortality rates across six continents. Methodology: The scientific literature was illustrated to find the correlation between the risk factors and resulting data to map, the approaches practiced concerning certain prevention strategies, in particular to alteration in behaviors such as reduction to UV-light exposure, screening and prevention in the progression of the disease. Results: The incidence of the disease is highest in Australia and New Zealand and lowest in Asian countries. A global survey was done on disease burden in 2018, in which signposts Incidence and mortality are 33.3 ASR and 4.8 ASR, respectively, in New Zealand and 33.6 ASR and 3.2 ASR, respectively, in Australia for melanoma skin cancer. The resistance of skin cancer to topical chemotherapy has turned the attention to natural therapeutics, including herbs, plant extracts and nutraceuticals. Conclusion: In difficult circumstances, a change in adaptive behavior and cognitive development can reduce the disease burden worldwide. Natural therapeutics can be used to exert anti-inflammatory, anti-proliferative and anti-tumorigenic by modulating the signaling pathways and other physiological effects.

Keywords: Apoptosis, Anti-inflammatory, Incidence, Melanoma skin cancer, Mortality, Melanocytes, Non- melanoma skin cancer, Natural therapeutics, preventive approaches, Signaling pathways, Risk factors, UV- radiation exposure.