The Diversity of Uses for Cellulose Sulphate Encapsulation

Author(s): John A. Dangerfield, Brian Salmons, Randolph Corteling, Jean-Pierre Abastado, John Sinden, Walter H. Gunzburg and Eva M. Brandtner

Pp: 70-92 (23)

* (Excluding Mailing and Handling)

Abstract

In this chapter we propose sodium cellulose sulphate (SCS) as a prime candidate for clinical application of encapsulated cells and present data for uses of SCS encapsulation for the direct delivery of therapeutic antibodies and advanced approaches for stem cell therapy. We also provide a simple lab protocol allowing researchers to make capsules at the bench without the need for expensive machinery.

Keywords: Live cell encapsulation, bioencapsulation, sodium cellulose sulphate, therapeutic antibodies, biomolecule release, long-term release, long-term survival, stem cells, biocompatibility, GMP manufacturing, immune protection, patient safety, storage capability, localisation, removability.