Unveiling the Potency of Phyto-Constituents to Target TNBC: Mechanism to Therapeutics

The development of an effective therapeutic approach against TNBC is a formidable challenge at present. Efficacy and drug resistance issues in response to adjuvant and neoadjuvant chemotherapy have prompted the development of new therapeutic regimens. In this concern, the scientific community has started exploring natural sources including medicinal plants exhibiting anti-cancer activity for their potent inhibitory potential against TNBC. The comprehensive analysis underlying the molecular mechanism of action of these natural bio-compounds provided substantial evidence to subject a few of these for clinical application. This chapter highlighted the momentous phytoconstituents as a genetic or epigenetic modulator by inducing demethylation and histone deacetylation in TNBC. Bioactive phytoconstituents including berberine, luteolin, cantharidin, saikosaponin D, wogonoside, and others targeted cell proliferation, metastasis, angiogenesis, autophagy, and induced apoptosis in TNBC. Furthermore, combinational therapy comprising phytoconstituents and chemotherapeutic drugs was explored to improve the clinical outcome of the disease. Additionally, drug ability parameters including bioavailability and bio-absorption of these phytoconstituents were also discussed. 

Keywords: Absorption, Berberine, Bioavailability, Cantharidin, Chemosensitization, Combinational therapy, Curcumin, Demethylation, DNMT1, Epigenetic modulator, Gambogic acid, Histone deacetylation, hTERT, Liposome, Luteolin, Microencapsulation, Phytochemicals, Saikosaponin, Solubility, Synergistic effect, Wogonoside.