Microarray Applications in Occlusive Vascular Disease

Jing      Chen; Traci      T. Goodchild; Brigitta      C. Brott; Jinsheng      Li; Spencer      B. King III; Nicolas      Chronos; Hong      Jiang; Dongming      Hou

Abstract

Interventional cardiology procedures and drug therapy have been widely applied for the treatment of occlusive vascular disease. However, there remains a critical lack of understanding of the disease process at a molecular level. Microarray technology has the unique advantage in the ability to analyze thousands of genes simultaneously. So far, several studies based on microarray analysis have already provided valuable expression data in diseases such as atherosclerosis and in-stent stenosis. This review summarizes: a) latest microarray research indentifying gene-expression profiles; b) the methodological analysis of the available microarray studies; c) generation of biological processes or pathways; d) detection of better diagnostic and therapeutic targets in atherosclerosis and in-stent stenosis. Further improvements in microarray interpretation as well as in study design, combined with definition and evaluation in the clinical arena, will enhance our understanding of the causes and mechanisms contributing to occlusive vascular diseases, and therefore will help to improve treatment of patients suffering from these diseases.

Keywords: Microarray, gene ontology, occlusive vascular disease, atherosclerosis, in-stent restenosis, gene expression, inflammation, oxidative stress, vascular smooth muscle cell, endothelial cell